Kindler Syndrome is the rarest type of EB. Blisters form in any skin layer and internal organs. Kindler Syndrome is caused by mutations in the gene FERMT1, which holds the instructions to make the protein kindlin-1. Individuals with Kindler Syndrome have a high sensitivity to UV rays from the sun and have an increased risk for squamous cell carcinoma, especially in the mouth.
Other EB Subtypes
Click below to learn about the other 3 major subtypes of Epidermolysis Bullosa: EB Simplex, Junctional EB, and Dystrophic EB.