Epidermolysis Bullosa is a family of rare genetic disorders that affect the body's largest organ: the skin. Individuals with EB lack critical proteins that bind the skin's two layers together. Without these proteins, the skin tears apart, blisters, and shears off leading to severe pain, disfigurement, and wounds that may never heal.

Sources

“Epidermolysis Bullosa Simplex - Genetics Home Reference - NIH.” U.S. National Library of Medicine, National Institutes of Health,  2018, ghr.nlm.nih.gov/condition/epidermolysis-bullosa-simplex.
“Junctional Epidermolysis Bullosa - Genetics Home Reference - NIH.” U.S. National Library of Medicine, National Institutes of Health, 2018, ghr.nlm.nih.gov/condition/junctional-epidermolysis-bullosa.​​
“Dystrophic Epidermolysis Bullosa - Genetics Home Reference - NIH.” U.S. National Library of Medicine, National Institutes of Health, 2018, ghr.nlm.nih.gov/condition/dystrophic-epidermolysis-bullosa.
“Kindler Syndrome - Genetics Home Reference - NIH.” U.S. National Library of Medicine, National Institutes of Health, 2018, ghr.nlm.nih.gov/condition/kindler-syndrome.
“Dominant Dystrophic Epidermolysis Bullosa.” Genetic and Rare Diseases Information Center, U.S. Department of Health and Human Services, rarediseases.info.nih.gov/diseases/2139/dominant-dystrophic-epidermolysis-bullosa.
Yancey, Kim B., and Helmut Hintner. "Non-herlitz junctional epidermolysis bullosa." Dermatologic clinics 28.1 (2010): 67-77.