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eb simplex (EBS)

About EB Simplex

EB Simplex (EBS) is the most common form of EB. Blisters form in the epidermis, or outer layer of skin. It is caused by mutations in the genes KRT5 or KRT14, which hold the instructions to make the proteins keratin 5 and keratin 14, respectively. There are 4 major types of EBS: Localized, Dowling-Meara, Generalized, and EBS with Mottled Pigmentation. Depending on the subtype, individuals with EBS experience mild to severe symptoms. Blisters are commonly found on the hands and feet, but can be widespread.

Life with EB Simplex

Meet Anna: Click on her photo to read about her life with EBS.
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Back to "What is EB?"

Other EB Subtypes

Click below to learn about the other 3 major subtypes of EB
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  • Epidermolysis Bullosa
    • What is EB?
    • Life with EB
    • Resources
  • Research
    • Our Impact
    • Scientific Advisory Board
    • Clinical Trials
    • Community Council
    • Apply for a Grant
  • Get Involved
    • Donate
    • Sponsor
    • EB Active
    • Events >
      • Venture Into Cures
    • The Effect
    • Shop
    • Accelerator Fund
  • Media
    • Press
    • Videos
  • About Us
    • Our Mission
    • Financials
    • Venture Philanthropy
    • Supporter Spotlight
    • Leadership >
      • Board of Directors
      • Staff
      • Founders
  • Donate