About EB Simplex
EB Simplex (EBS) is the most common form of EB. Blisters form in the epidermis, or outer layer of skin. It is caused by mutations in the genes KRT5 or KRT14, which hold the instructions to make the proteins keratin 5 and keratin 14, respectively. There are 4 major types of EBS: Localized, Dowling-Meara, Generalized, and EBS with Mottled Pigmentation. Depending on the subtype, individuals with EBS experience mild to severe symptoms. Blisters are commonly found on the hands and feet, but can be widespread.